The Premier League new boys head into the third-round clash buoyed by Saturday's impressive 2-0 win at Wolves.
Shandon Baptiste is unavailable to face Latics through suspension and Bees boss Frank says they have no fresh injuries to contend with.
Oldham head to Brentford Community Stadium bottom of the English Football League.
Keith Curle's side sit bottom of Sky Bet League Two following their 0-0 home draw with promoted Hartlepool at the weekend.
A lengthy injury list has compounded matters for Oldham.