Meanwhile, QPR make the short trip to face the Bees having won three of their last five games, a run which has moved the club clear of the relegation zone.
With the likes of Norwich City and Bournemouth threatening to move clear at the top of the table, Brentford are under pressure to turn draws into wins during the winter.
For long periods against Barnsley on Tuesday evening, it appeared that a fifth stalemate in six matches would be recorded, leaving the Bees as close to mid-table as the playoffs.
However, Ivan Toney's second-half winner has put a different spin on matters, providing Brentford with a 10-point haul from their last half-a-dozen outings.
By Championship standards, that is a solid return, but Thomas Frank knows that his players must find some form at their new stadium if they are to make progress up the standings.
Brentford have recorded just two victories from six matches at the ground, as well as being restricted to four goals from their last 360 minutes of action.
Unlike their hosts, QPR have found getting on the scoresheet a far easier task with nine strikes coming in their last five encounters.
Three of those were netted in a thriller with Rotherham United earlier this week as Mark Warburton's side made further progress up the standings.
However, improvements are required at the other end of the pitch with QPR having now conceded 11 times during their last six fixtures, a return which will only encourage their rivals ahead of this contest.
Brentford Championship form: DWDDDW
Queens Park Rangers Championship form: LWWLDW
Frank could hand a recall to Emiliano Marcondes after his half-time introduction helped change the flow of the game at Oakwell.
Given the three-day turnaround, Josh Dasilva may not have enough time to recover from the knock which he received on Tuesday evening.
Warburton has injury concerns in defence after Conor Matherson suffered a broken nose and Yoann Barbet picked up a knock against Rotherham.
However, Rob Dickie is expected to come back into contention after missing that game with an ankle problem.
Brentford possible starting lineup:
Raya; Dalsgaard, Jansson, Pinnock, Henry; Jensen, Janelt, Marcondes; Mbuemo, Toney, Fosu-Henry
Queens Park Rangers possible starting lineup:
Dieng; Kakay, Dickie, Barbet, Hamalainen; Ball, Cameron; Osayi-Samuel, Chair, Willock; Dykes
We say: Brentford 2-1 Queens Park Rangers
Despite their contrasting trajectories in recent years, we expect a hard-fought battle between the London neighbours. However, while the visitors could provide a threat in attack, Brentford may take advantage at the other end, improving on their recent failings in front of goal.
Top betting tip
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