Ceara vs. The Strongest (Wednesday, 11.15pm)
The hosts hold a slender lead ahead of Wednesday's contest after winning 2-1 in Bolivia last week.
We say: Ceara 2-1 The Strongest
The Strongest know that they need to win to have any hope of reaching the quarter finals, and their quest for the win could leave them vulnerable defensively, which Ceara could take advantage of to clinch a second leg victory.
Santos vs. Tachira (Thursday, 1.30am)
The first game was an even one that finished 1-1, giving neither side an advantage heading into this one, leaving everything to play for.
We say: Santos 1-2 Deportivo Tachira
The fixture last time proved to be closely contested, and that is something that will no doubt be the case again as both teams aim to progress into the next round.
Santos have struggled for form in all competitions as of late, and that lack of confidence is something that could prove to be their downfall here.
Melgar vs. Deportivo Cali (Thursday, 1.30am)
The hosts followed that with another draw, and that is something that they will now be hoping to turn into a victory in front of their own fans.
We say: Melgar 2-0 Deportivo Cali
Melgar might have struggled to create many chances offensively during their previous encounter with Deportivo Cali, but they still head into this game as the favourites to win.
The hosts have been consistent and dominant throughout the campaign in all competitions, and that is something that should help guide them to a victory here.