The Scotland attacker and defender Greg Taylor did not travel to Denmark for the first leg of the last-32 clash, nor did longer-term injured defender Hatem Abd Elhamed.
As a partner to Odsonne Edouard, Griffiths has been key to the 3-5-2 formation that Lennon has preferred to the 4-2-3-1 since the start of 2020, which has brought nine wins out of nine in all competitions.
Speaking at the Parken stadium, Lennon said: "Hatem Elhamed did not travel, Greg Taylor picked up an injury at the weekend and Leigh Griffiths picked up an injury in training, a slight twinge.
"I'm hoping the latter two will be fit for the weekend.
"We can use both systems, we are comfortable with both and we have a fair idea of how we want to play tomorrow.
"I expect a difficult game, tactically they are smart. We are in good form, confidence is good. I am not taking anything for granted but we are looking forward to the game.
"The stadium is magnificent, I have just been out looking at it, the pitch has been re-laid and looks good and the players will get very excited about the game when they get here.
"I touched on a couple of injuries but I have a good complement of players here as well.
"Confidence is good but obviously we are not taking anything for granted in terms of Copenhagen.
"They are a strong team and they are difficult to beat."