The Hoops have lost just two of their last 44 home league games, while Livingston could extend their winning run in the top-flight to seven matches if they were to secure three points this weekend.
Celtic endured another difficult week as they were heavily criticised for a controversial warm-weather training trip to Dubai, which resulted in defender Christopher Jullien contracting coronavirus.
Along with Jullien, another 13 players and manager Neil Lennon – who were all deemed close contacts with the Frenchman – were forced into self-isolation, which resulted in the Hoops naming a depleted side that drew 1-1 at home to Hibernian on Monday night.
The draw with Hibs has left Lennon's side an enormous 21 points behind rivals Rangers at the summit of the Scottish Premiership and the gap at the top would still remain huge even if they were to win their three games in hand.
Celtic head into their clash with Livingston having won 11 of their previous 12 top-flight home games against them, drawing the other encounter 0-0 in April 2019.
Victory on Saturday would be their first in three league matches and could move them eight points clear of Aberdeen in third if they were to lose away to Ross County.
Livingston were unable to extend their winning league run to seven matches on Wednesday night as their home game with Aberdeen was postponed for the second time.
The team's fixture against the Dons, originally scheduled for December 30, was postponed on the day because of a frozen pitch and was called off again on Wednesday, this time due to a waterlogged pitch.
Manager David Martindale has transformed his Lions side since his appointment in November, winning all eight matches in charge, and he will be hoping to continue this run against what is expected to be an under-strength Celtic side on Saturday.
However, Livingston have a dismal record against the Hoops; from 2001 to 2018, the Lions lost 16 consecutive league meetings with Celtic, although they have since avoided defeat in four of their last six against them in the Scottish Premiership.
Livingston have scored two or more goals in all six league victories under Martindale and have also conceded just three times in this period.
Securing the three points this weekend would keep the Lions in fifth place but could move them four points behind Hibernian in fourth if they were to lose at home to Kilmarnock.
Celtic Scottish Premiership form: WWWWLD
Celtic form (all competitions): WWWWLD
Livingston Scottish Premiership form: WWWWWW
Livingston form (all competitions): WWWWWW
Celtic could be forced to name the same starting lineup that drew with Hibernian on Monday.
American forward Cameron Harper, who made his league debut for Celtic against Hibs, could start once again up front, as up to six forward players – Odsonne Edouard, Leigh Griffiths, Albian Ajeti, Patryk Klimala, Mohamed Elyounoussi and Ryan Christie – are expected to remain in self-isolation.
With 11 matches to play in just 35 days, Livingston boss Martindale has made it clear that his team selection would not be impacted by their congested schedule.
Defender Jack Fitzwater, who has missed the previous three matches, was expected to make the bench against Aberdeen and so is likely to start as a substitute on Saturday.
Celtic possible starting lineup:
Hazard; Frimpong, Welsh, Duffy, Laxalt; Soro, McGregor; Turnbull, Rogic, Johnston; Harper
Livingston possible starting lineup:
Stryjek; Devlin, Ambrose, Guthrie, Brown; Bartley, Holt, Mullin, Pittman, Sibbald; Robinson
We say: Celtic 1-1 Livingston
Celtic are to view each league fixture they face as a must-win if they are to have any hope of narrowing the gap between themselves and Rangers; their clash with an inform Livingston outfit could prove to be a tricky test, especially with a weaker side, which could see the Hoops drop more points on Saturday.