Separated by four points, both sides occupy the top two spots in the standings, with the hosts leading the league with 21 points from 10 matches.
Central Coast Mariners have been the dark horses in the A-League, following their disappointing 11th-placed finish in the previous campaign.
The Gosford outfit started February with a run of three wins on the bounce, pulling four points clear at the top of the table.
Alen Stajcic's side quickly bounced back to winning ways when they squared off with Perth Glory on Tuesday, claiming a 2-1 at the HBF Park.
Macarthur's three-game unbeaten streak was ended by free-scoring Western United, who cruised to a comfortable 4-1 win two weeks ago.
Like Monday's hosts, they quickly returned to winning ways when they travelled to the Leichhardt Oval to take on Sydney FC last time out.
Following a 2-0 win in January's reverse fixture, the Mariners will be aiming for back-to-back wins against the visitors, who come into this tie with a fine away record, having picked up four wins from five games on the road.
They take on a side who boast the second-best home record this term, only behind Adelaide United, and this promises to be an entertaining contest.
On the other hand, Macarthur will be without the services of veteran full-back James Meredith, who picked up a groin injury in the game against Western United.
Another absentee for the visitors is Australian-born forward Milisav Popovic, who is yet to make an appearance since making his move from Austrian-based side Lafnitz.
Matt Derbyshire has been a standout performer in the A-League, sitting second in the scoring charts with seven goals, and he will once again lead the Bulls' attack.
Central Coast Mariners possible starting lineup:
Birighitti; Clisby, Rowles, Tongyik, Nigro; Bouman, Stensness, Bozanic, De Silva; Kuol, Urena
Macarthur possible starting lineup:
Federici; Meredith, Milligan, Jovanovic, Franjic; Etxebarria, Genreau; Najjar, Puyo, Susaeta; Derbyshire
We say: Central Coast Mariners 2-1 Macarthur
Both sides have been impressive so far this season, but despite being evenly matched on paper, we predict the Mariners grab all three points on Monday and extend their lead at the top of the table.