A poor run of form has left the Blues in ninth position in the standings, six points adrift of the Champions League places and 10 behind leaders Manchester United.
Recent results have heaped the pressure on manager Frank Lampard, who will be aware that another setback will only increase speculation regarding his future.
Chelsea have failed to win on the travels since November 21, losing fixtures at Everton, Wolverhampton Wanderers and Arsenal respectively.
If they suffer the same fate at Craven Cottage, it will be the first time since December 2000 that they have recorded four successive defeats on the road.
Fulham, who have registered five top-flight draws in a row, are searching for their first win in a Premier League London derby since the start of 2014. body check tags ::