After last weekend's derby success over Tottenham Hotspur, the Blues sit three points ahead of nearest rivals Manchester United.
However, having been outclassed by Bayern Munich in the Champions League in midweek, Frank Lampard may have a tough task to lift his players ahead of the trip to the South coast.
Here, Sports Mole predicts how the West Londoners may line up for the game at the Vitality Stadium.
With Tammy Abraham having pulled up in the cool-down on Tuesday night, Olivier Giroud is likely to retain his place in the starting lineup for the third successive match.
Although Mason Mount is likely to keep his spot in a creative role behind the Frenchman, Willian may be recalled to the right-hand side.
While Callum Hudson-Odoi is in line to return to the squad after a hamstring injury, the winger may only feature among the replacements.
The same can be said of Ruben Loftus-Cheek, who has been involved in full training for a couple of weeks since recovering from a serious Achilles injury. body check tags ::