Crystal Palace vs. Man City (Saturday, 12.30pm)
The hosts will have had five days to recover from their 2-1 defeat at the hands of Leicester City on Monday night, while Man City overcame Paris Saint-Germain by the same scoreline in the first leg of their Champions League semi-final in midweek.
We say: Crystal Palace 0-3 Manchester City
A raft of expected changes from Man City could lead Palace to feel optimistic about their chances of a shock result, but City's form on the road is unparalleled.
Guardiola's side need other results to go their way to secure the Premier League title with four games to spare, and they should give themselves the best chance possible of confirming their status as champions with a routine win at Selhurst Park.
Brighton vs. Leeds (Saturday, 3.00pm)
We say: Brighton & Hove Albion 1-1 Leeds United
Leeds have not drawn a single match on their travels in the Premier League this season, but Brighton have shared the points on eight occasions in the league at the Amex; we are expecting a tight match on Saturday afternoon and have ultimately settled on a low-scoring draw here.
Chelsea vs. Fulham (Saturday, 5.30pm)
We say: Chelsea 2-0 Fulham
Fulham will aim to take advantage of Chelsea's fatigued legs this weekend, but the Blues will equally endeavour to capitalise on the Cottagers' low morale and pile more misery on their relegation-threatened rivals.
Tuchel has plenty of options for a change and a near fully-fit squad to pick from for this London derby, and even with their European exploits in mind, we cannot see the Blues slipping up here.
Everton vs. Aston Villa (Saturday, 8.00pm)
The Toffees, who beat Arsenal last time out, are currently eighth in the table, six points off fourth-placed Chelsea, while Villa occupy 11th position, having picked up 45 points from 32 matches this term.
We say: Everton 1-0 Aston Villa
Everton's home form this season has been disappointing, and Villa are more than capable of making this a tough match for Ancelotti's side. The Toffees need to win as they chase a top-four spot, though, and we are backing the Merseyside club to emerge victorious courtesy of a 1-0 success.