Sheff Utd vs. Man City (Saturday, 12.30pm)
Bramall Lane will host Saturday's early start in the Premier League with Sheffield United welcoming Manchester City for what is a hugely important game for both teams.
The Blades have only picked up one point from their six league games this season to sit 19th in the table, while City are down in 13th with eight points to show from their opening five matches of 2020-21.
We say: Sheffield United 0-2 Manchester City
Sheffield United put in a much improved performance against Liverpool last time out, and they are in for another tough examination this weekend. City are missing some key players, especially in the final third of the field, but we expect the visitors to claim all three points at Bramall Lane.
Our tipster partners are predicting an away win.
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> How Manchester City could line up against Sheffield United
> Man City injury, suspension list vs. Sheffield United
Burnley vs. Chelsea (Saturday, 3.00pm)
Burnley will aspire to win their first Premier League game of the season at the sixth attempt when they welcome Chelsea to Turf Moor for Saturday's fixture.
The Blues do not have much to boast about domestically either, but Frank Lampard's men eased to a 4-0 victory over FC Krasnodar in the Champions League on Wednesday.
We say: Burnley 1-3 Chelsea
Burnley must start improving their results soon lest they risk becoming early candidates for the drop, but there are certainly not expected to do so against a talented Chelsea side brimming with confidence following a vital Champions League win, and we can only see the Blues coming away with all three points on Saturday.
Our tipster partners are predicting an away win.
> Click here to read our full preview for this match
> How Chelsea could line up against Burnley
> Chelsea injury, suspension list vs. Burnley
Liverpool vs. West Ham (Saturday, 5.30pm)
Premier League champions Liverpool will aspire to win their fourth game on the bounce in all competitions when the Reds welcome West Ham United to Anfield for Saturday's top-flight showdown.
The hosts enjoyed a 2-0 victory over FC Midtjylland in the Champions League in midweek, whereas West Ham's most recent fixture saw them hold Manchester City to a 1-1 draw in the league.
We say: Liverpool 2-1 West Ham United
Any team would struggle with the loss of one of their top defenders, and Liverpool's growing list of injuries is certainly a major concern for Klopp amid an unforgiving fixture schedule. The Reds are facing a challenging fixture against a West Ham side who have made a habit of taking points off of some of the big sides recently, but we still think the champions will do enough to get over the line.
Our tipster partners are predicting a home win.
> Click here to read our full preview for this match