The Belgium international has only netted once in five games - that goal coming against Chesterfield in the FA Cup - but the summer arrival spearheads an attack in what appears to be a 4-2-3-1 formation.
Thomas Tuchel used a similar system for the recent EFL Cup tie against the same opposition at Stamford Bridge, with Chelsea having the ability to switch to a back five when defending.
Trevoh Chalobah has returned to the substitutes' bench after a hamstring injury, despite Tuchel insisting on Friday that the academy graduate would not have recovered in time.
Chelsea: Arrizabalaga; Azpilicueta, Silva, Rudiger, Sarr; Jorginho, Kovacic; Ziyech, Mount, Hudson-Odoi; Lukaku
Subs: Bettinelli, Chalobah, Alonso, Kante, Barkley, Saul, Havertz, Pulisic, Werner
Tottenham Hotspur: Lloris; Tanganga, Dier, Sanchez; Doherty, Hojbjerg, Winks, Davies; Bergwijn, Kane, Sessegnon
Subs: Gollini, Reguilon, Rodon, Gil, Royal, Moura, Skipp, White, Scarlett body check tags ::