The Denmark defender has recovered from a muscle problem to be available.
Striker Aaron Connolly could return to Brighton's squad following a foot injury.
The Republic of Ireland international has not featured since the 1-0 defeat to West Brom on February 27 but has trained freely during the past week.
Chelsea provisional squad: Arrizabalaga, Rudiger, Alonso, Christensen, Jorginho, Silva, Kante, Abraham, Pulisic, Werner, Caballero, Zouma, Mendy, Giroud, Mount, Hudson-Odoi, Chilwell, Ziyech, James, Azpilicueta, Havertz, Palmieri, Gilmour.
Brighton provisional squad: Sanchez, Steele, White, Webster, Dunk, Veltman, Burn, Karbownik, Bissouma, Gross, Lallana, Propper, Caicedo, Mac Allister, Alzate, Moder, Jahanbakhsh, Izquierdo, Trossard, Maupay, Welbeck, Zeqiri, Tau, Connolly.