Gareth Southgate insists England's friendly with Wales means as much to his players as it will to the visitors at Wembley on Thursday night.
The home nations meet for the first time since the Three Lions won a Euro 2016 group-stage match.
Since then both Southgate and Ryan Giggs have been appointed as manager of their respective country.
The game will be England's first at Wembley since the coronavirus pandemic meant supporters were not able to attend matches.
"The strength in depth is going to be tested, but that's why we give players chances and then it's up to them to stay in the team."
Wales have not beaten England since 1984 and are without a Wembley win since 1977.
"It would be an amazing feat if we won," Giggs said.
"England have got some quality players and real strength in depth.
"They could pick two or three teams and we know whatever team they put out, it's going to be a difficult match for us.
"But we're excited about the game and it will be a great occasion for our players."