Gareth Southgate's side squandered a number of chances on their way to a quiet goalless draw with Croatia on Friday night, leaving both World Cup semi-finalists five points adrift of the perfect Spain in Group A4.
The threat of relegation could loom should England fail to exact revenge for their 2-1 defeat at Wembley last month, but the odds will be against Southgate's inexperienced side.
Here, Sports Mole looks at how they could line up in Seville.
Southgate switched to four at the back for the first time in a year against Croatia, and one of the biggest decisions to make will be whether to stick with that system or revert to his 3-1-4-2 formation.
Suspensions for John Stones and Jordan Henderson - both of whom picked up yellow cards against Croatia - may tilt the balance in favour of the four-man defence, although Southgate does have options at the back with Kyle Walker and Joe Gomez able to play in the middle along with Harry Maguire.
Lewis Dunk is another alternative as he waits for his England debut - one of five remaining uncapped players in the squad along with Marcus Bettinelli, Nathaniel Chalobah, James Maddison and Mason Mount.
Maddison's form this season makes him the most likely to make a full debut from that quintet, and a change back to the World Cup formation would appear to boost his chances of starting.
Jadon Sancho made his debut against Croatia, impressing off the bench, although he could be a victim of the change of formation should Southgate revert to three at the back.