Here, Sports Mole looks at how they could line up against Gareth Southgate's side.
Spain are missing the likes of Dani Carvajal, Jordi Alba, Isco and Diego Costa from their squad at the moment, but that did not prevent them from thrashing Wales with a team weaker than the one they are expected to field on Monday.
The likes of Sergio Busquets, Thiago Alcantara and Marco Asensio are among the players who could be drafted into the starting lineup, with the latter having scored one and created four more in Spain's last Nations League match.
Paco Alcacer scored twice in Cardiff and is also in fine form for Borussia Dortmund at club level, so should retain his place, but Rodrigo Moreno is expected to lead the line ahead of Chelsea's Alvaro Morata.
The strength in depth of the Spanish midfield means that almost any trio could be selected without losing much quality, with Koke vying with the likes of Saul Niguez, Dani Ceballos and Rodri Hernandez for a place in the team.
> Click here to see how England could line up for this fixture body check tags ::