The Leeds United man was taken off early with a "severe dead leg" during Tuesday's draw with Germany and may be forced to take his place on the sidelines alongside Fikayo Tomori.
Gareth Southgate still has the option to bring in Reece James at right-back for Kyle Walker and may be tempted to do so here, with Kieran Trippier holding the fort on the opposite side and Aaron Ramsdale displacing Jordan Pickford in goal.
Harry Maguire may also be in need of a rest as Marc Guehi partners John Stones, while Phillips's likely absence opens the door for Jude Bellingham to return alongside James Ward-Prowse, with Declan Rice granted a break.
Bukayo Saka and Raheem Sterling's spots may also be at risk this week, with Jack Grealish and Jarrod Bowen - the former of whom provided a bright spark off the bench in Munich - hopeful of joining Mason Mount in the final third.
England possible starting lineup: Ramsdale; James, Stones, Guehi, Trippier; Ward-Prowse, Bellingham; Bowen, Mount, Grealish; Kane
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