Roda JC's relegation from the Eredivisie was confirmed on Saturday.
A 3-0 loss at FC Twente - their 10th defeat in 12 games - means that, with just two league matches remaining, Jon Dahl Tomasson's men can finish no higher than 16th.
Torgeir Borven scored a first-half brace before Kyle Ebecilio completed a comfortable victory for Twente after the break.
A dismal league campaign for Roda has seen the Kerkrade side record six wins, eight draws and 18 defeats, scoring 42 goals and conceding 67 in the process.