Fluminense vs. River Plate (Thursday, 11.00pm)
Brazilian side Fluminense welcome Argentinian giants River Plate to Rio de Janeiro on Thursday evening for their opening fixture in the Copa Libertadores group stages.
The two teams head to the Maracana having won their last three games in all competitions, scoring 18 goals between them in the process.
We say: Fluminense 1-3 River Plate
Fluminense have kept five clean sheets in their last eight matches, but their chances of keeping out River Plate, who have scored 16 goals in their last six matches, seem slim.
We feel that the Argentines, who are the favourites for this clash, will be too strong for the hosts and should be able to claim all three points at the Maracana.
> Click here to read our full preview for this match
Atletico Nacional vs. Catolica (Friday, 1.00am)
Atletico Nacional welcome Universidad Catolica to Medellin on Thursday evening for their opening fixture in the Copa Libertadores group stages.
The two teams, who are joined in Group F with Club Nacional and Argentinos Juniors, will be looking to open their accounts with three points at the Estadio Atanasio Girardot.
We say: Atletico Nacional 2-0 Universidad Catolica
Both Atletico Nacional and Universidad Catalica head into Thursday's clash in good form, with the Colombian side having scored 11 goals in their last two matches and the visitors winning four of their last five games.
The hosts will be slight favourites for this encounter, and we feel that they have enough quality to secure all three points in Medellin.
> Click here to read our full preview for this match
Junior vs. Santa Fe (Friday, 3.00am)
Two Colombian sides will lock horns in the group stages of the Copa Libertadores when Atletico Junior host Santa Fe on Thursday evening.
Both teams, who are in Group D with Fluminense and River Plate, will be looking to open their accounts with three points at the Estadio Metropolitano Roberto Melendez.
We say: Atletico Junior 1-1 Santa Fe
Both Atletico Junior and Santa Fe will fancy their chances of getting off to a strong start in Group D and claiming all three points on Thursday. However, with little to separate the two Colombian teams, a score draw could be on the cards in Barranquilla.
