Four days on from suffering their first Premier League loss of the campaign, Jurgen Klopp's men must avoid coming unstuck against Wolves in this competition for the second time in three seasons.
The Reds have played 11 games since November 24, nine of those in the Premier League, but Klopp is expected to name a fairly strong starting lineup in the West Midlands.
Here, Sports Mole looks at how the Premier League leaders could line up.
Klopp remains without Gomez and Matip in central defence, while Moreno has been struggling with a back injury and Nathaniel Clyne has been sent to Bournemouth, so the back four may remain unchanged from the 2-1 loss at Manchester City.
Should Klopp stick with a 4-3-3 formation, that leaves a spot up for grabs on the left, which may well be taken by Sadio Mane, despite the Senegal forward being used 10 times over the past six weeks.