Liverpool boss Kenny Dalglish has made three changes to the side that lost to Manchester United in the Premier League last weekend.
Andy Carroll returns to partner Luis Suarez in attack, while Jamie Carragher and Charlie Adam also return to the team.
Brighton, meanwhile, give starts to Sam Vokes and Will Buckley, who scored against Newcastle in the previous round.
Liverpool: Reina; Johnson, Carragher, Skrtel, Enrique; Henderson, Gerrard, Adam, Downing; Suarez, Carroll.
Brighton: Brezovan; Calderon, Greer, Dunk, El Abd; Buckley, Navarri, Bridcutt, Lua Lua; Barnes, Vokes.
