The Magpies head into the fixture in good form, having taken seven points from their last three games, and will look to impress in their final home game of the campaign.
Despite a disappointing defeat to Barcelona in the Champions League semi-final on Wednesday, Jurgen Klopp's side travel to St James' Park with high confidence after winning seven consecutive league games.
Liverpool will need to take all three points if they hope to continue their challenge for the title and keep pressure on current league frontrunners Manchester City.
Here, Sports Mole takes a look at how Newcastle could line up against the Merseyside giants.
Out: Longstaff (knee), Lejeune (knee), Almiron (hamstring)
Doubtful: Perez (hip)
Rafael Benitez will likely stick with the same formation fielded in his most recent outings, aiming to soak up pressure and hit Liverpool on the counter-attack.
Salomon Rondon will once again lead the line as the lone target man having been directly involved in 44% of Newcastle's goals this season - the second-highest ratio in the league behind only Eden Hazard.