Lyon head coach Remi Garde has made three changes to the side that beat Sochaux last weekend.
Ahead of their Champions League qualifying return leg on Wednesday, Clement Grenier, Steed Malbranque and Yassine Benzia make way for Bakary Kone, Gael Danic and Fares Bahlouli.
Reims boss Hubert Fournier has named an unchanged team after his side shocked Lille last time out.
Grzegorz Krychowiak, Eliran Atar and Mads Albaek all retain their places despite being substituted in their last match.
Lyon: A.Lopes, M.Lopes, Bisevac, Kone, Bedimo, Gonalons, Fofana, Gourcuff, Bahlouli, Lacazette, Danic
Reims: Agassa, Glombard, Mandi, Tacalfred, Weber, Albaek, Atar, Krychowiak, Oniangue, Courtet, Fortes