Pep Guardiola's side play a day earlier than each of their main rivals for the top-flight crown, but that may only lead to the pressure increasing on Liverpool, Tottenham Hotspur, Chelsea and Arsenal.
City have put together a 14-match unbeaten run in all competitions, with 12 wins, 44 goals and 10 clean sheets all coming during that period.
Guardiola has a number of selection dilemmas ahead of Saturday's game, and here Sports Mole looks at how his team could line up at the Etihad Stadium.
Ilkay Gundogan, Bernardo Silva and Gabriel Jesus all missed Tuesday's Champions League fixture in Lyon, but Guardiola expects to have each of the trio available to play some part of this weekend's encounter.
Guardiola could look to rotate some of his key men due to the club's upcoming schedule, and that may lead to Bernardo coming in for Raheem Sterling on the right flank.
Fabian Delph is a likely inclusion having started the game in France on the bench, but whether the England international starts at left-back or in midfield could depend on the fitness of Gundogan.
The game is likely to come too soon for Kevin De Bruyne, with it having previously been reported that the Belgian playmaker is aiming to make his comeback from a knee injury ahead of next weekend's meeting with Chelsea.