The Frenchman missed Friday's defeat at West Ham with a knock and is not expected to return in time for the visit of Pep Guardiola's men.
City are still without leading scorer Sergio Aguero, who has been sidelined since knee surgery last month.
Back-up goalkeeper Claudio Bravo is again doubtful with the muscular problem that kept him out of Saturday's FA Cup semi-final loss to Arsenal.
City have no fresh injury concerns following the defeat at Wembley.
Watford provisional squad: Foster, Gomes, Masina, Femenia, Holebas, Mariappa, Cathcart, Dawson, Kabasele, Cleverley, Chalobah, Hughes, Doucoure, Quina, Penaranda, Pereyra, Sarr, Deeney, Welbeck, Pedro, Gray, Pussetto.
Manchester City provisional squad: Ederson, Carson, Cancelo, Walker, Stones, Otamendi, Garcia, Laporte, Zinchenko, Mendy, Fernandinho, Gundogan, Rodri, De Bruyne, D Silva, B Silva, Mahrez, Foden, Sterling, Jesus, Harwood-Bellis, Doyle.