The summer transfer window has now closed, with Manchester City having again focused on bolstering their defence first and foremost.

Nathan Ake and Ruben Dias arrived for a combined sum of more than £100m, while Ferran Torres was another notable signing. Attention will now switch to the January window as Pep Guardiola's side attempt to win back the Premier League title.

Here, Sports Mole rounds up the latest news on possible comings and goings at the Etihad.

Sunday morning's Manchester City transfer talk news roundup:

Isco 'asks to leave Real Madrid in January'

Real Madrid midfielder Isco has reportedly informed the La Liga giants of his desire to leave the club in the January transfer window.

The Spain international has struggled to nail down a regular spot in Zinedine Zidane's first XI recently and has only started three of Real's seven La Liga games this season.

Isco was linked with a move to the Premier League throughout the summer - namely with Everton amid talk of a reunion with Carlo Ancelotti - although the Toffees boss has since denied those "bullshit" rumours.

However, according to Marca, Isco already has one foot out of the door at the Bernabeu after voicing his desire to leave through his father and agent, Francisco Alarcon, and Real are not prepared to stand in his way.

Isco still has just under two years left to run on his current deal at the Bernabeu, but with a spot in Spain's Euros squad at stake, the 28-year-old is understandably said to be keen to move elsewhere in search of regular first-team action.

Juventus, Manchester City and Arsenal have all been credited with an interest in Isco, who has amassed 51 goals in 313 games for Madrid since arriving from Malaga in 2013.

Premier League big six 'all interested in Sergio Ramos'

Liverpool, Manchester City, Manchester United, Chelsea, Arsenal and Tottenham Hotspur are all reportedly interested in signing Real Madrid centre-back Sergio Ramos.

The 34-year-old's existing deal at the Bernabeu is due to expire next June and as it stands he would be free to discuss terms with foreign clubs at the start of 2021.

Ramos is believed to want a two-year extension with Los Blancos, but it remains to be seen whether the Spanish champions are prepared to offer more than a 12-month deal.

According to 90min, the Premier League's big six clubs - Liverpool, City, United, Chelsea, Arsenal and Tottenham - have all contacted the Spaniard's representatives to express their interest.

The report claims that all six are considering the possibility of bringing him to England, but Ramos would have to signal that he wants to move to the Premier League.

The experienced defender has scored 100 goals in 660 appearances for Madrid, winning five La Liga titles and four Champions League crowns since arriving from Sevilla in 2005.

More transfer news from Manchester City:

Man City 'identify Darwin Nunez as potential Sergio Aguero successor'
Benfica forward Darwin Nunez emerges as a transfer target for Manchester City, according to a report. Read more.

Raheem Sterling set for new Manchester City deal?
Manchester City are reportedly ready to offer Raheem Sterling a bumper new contract after Pep Guardiola penned fresh terms at the Etihad Stadium. Read more.