Pep Guardiola will have been a satisfied man after City's efficient victory over Bournemouth last weekend.
An Aguero brace and a customary Raheem Sterling strike wrapped up the points for the champions on the South coast as returned City to winning ways after the dramatic 2-2 draw with Tottenham Hotspur the week before.
The Sky Blues created plenty of chances against Eddie Howe's expressive side and will expect the same volume of opportunities this weekend against Brighton.
City have not lost a home match since December, which happened to be against Brighton's fiercest rivals Palace, but will want to get their first triumph on home soil of the new campaign after Gabriel Jesus' late finish was denied by VAR against Spurs.
Kyle Walker's performance at Bournemouth was rash, and City supporters will be excited to see their new acquisition from Juventus.
Last weekend's man of the match David Silva may be rested, with the Spaniard's fitness and game-time having to be carefully managed, but fellow creator Kevin De Bruyne has looked a man rejuvenated in Guardiola's midfield.
Sergio Aguero has traditionally loved this kind of fixture at home to a bottom half side and will be chomping at the bit to score more goals after last weekend's brace.
With Liverpool looking ominously like last season's juggernaut, nothing but a win will do here for City, even at this early stage of the season.
Recent form: WDW
Brighton & Hove Albion
Graham Potter has had a mixed start to life on the South coast with his new side Brighton.
The 44-year-old got off to the perfect start with that stunning 3-0 victory over Watford at Vicarage Road.
Results since, however, have been a tad disappointing. The Seagulls have taken just one point from two very presentable home games against West Ham United and Southampton.
The Southampton defeat was forgivable, with Florin Andone's brainless 30th minute red card making life very difficult for his teammates, who slumped to a 2-0 defeat.
Glenn Murray's stoppage time winner did give fans something to cheer about in the Carabao Cup tie at Bristol Rovers on Tuesday night.
Potter has attempted to instil a different philosophy at Brighton. Gone are the days of playing primarily for a clean sheet under Chris Hughton - the former Swansea manager instead favours a patient approach involving defenders in a three-at-the-back system looking to pass out from the back.
As admirable as this new philosophy is, in a match as tough as this, it would not be a surprise if Brighton do go back to the Hughton 'hold what you have' game plan.
Recent form: WDL
Recent form (all competitions): WDLW
Pep Guardiola will once again be without a number of first-team stars for the match with Brighton.
Benjamin Mendy remains injured with a knee injury, and will need to time to get back up to speed after missing pre-season.
Gabriel Jesus missed the victory at Bournemouth with a hamstring problem picked up in training and will again miss out.
Manchester City possible starting lineup:
Ederson; Cancelo, Otamendi, Laporte, Zinchenko; De Bruyne, Rodri, Gundogan; B. Silva, Aguero, Sterling
Brighton & Hove Albion possible starting lineup:
Ryan; Duffy, Dunk, Burn; Montoya, Stephens, Propper, March; Gross, Murray, Trossard
Head To Head
Manchester City have won all four meetings with Brighton since the Seagulls' promotion to the Premier League, as well as in last season's FA Cup semi-final.
These two last met on the final day of last season, when Glenn Murray's header provided a brief scare before City wrapped up the title with an emphatic 4-1 win.
That Murray goal was one of just two that Brighton have scored against City since promotion, having conceded 11.
We say: Manchester City 3-0 Brighton & Hove Albion
City's well-oiled machine are just too strong for most teams in world football, let alone a bottom-half Premier League side. Even without Gabriel Jesus and Leroy Sane, the Sky Blues have firepower everywhere you look, and should win this match comfortably.