Manchester United's involvement in the semi-finals of last season's Europa League means that they will sit out the opening weekend, leaving a home game against Crystal Palace as their first match of the new campaign.
A tricky-looking October sees them face Tottenham Hotspur, Chelsea and Arsenal - all at Old Trafford - while they will face Manchester City in the derbies in December and March.
The other fixture always of interest is the Liverpool clash - especially so now that Liverpool are looking to equal United's tally of 20 top-flight titles - and the first of those takes place at Old Trafford in January before the reverse at the beginning of May.
The Red Devils host newly-promoted Fulham in their penultimate game of the season before ending the campaign away to Wolverhampton Wanderers.
SEPTEMBER
12: Burnley (a) POSTPONED
19: Crystal Palace (h)
26: Brighton (a)
OCTOBER
3: Tottenham (h)
17: Newcastle United (a)
24: Chelsea (h)
31: Arsenal (h)
NOVEMBER
7: Everton (a)
21: West Brom (h)
28: Southampton (a)
DECEMBER
5: West Ham (a)
12: Man City (h)
15: Sheffield United (a)
19: Leeds (h)
26: Leicester (a)
28: Wolves (h)
JANUARY
2: Aston Villa (h)
12: Fulham (a)
16: Liverpool (a)
26: Sheffield United (h)
30: Arsenal (a)
FEBRUARY
2: Southampton (h)
6: Everton (h)
13: West Brom (a)
20: Newcastle (h)
27: Chelsea (a)
MARCH
6: Man City (a)
13: West Ham (h)
20: Crystal Palace (a)
APRIL
3: Brighton (h)
10: Tottenham (a)
17: Burnley (h)
24: Leeds (a)
MAY
1: Liverpool (h)
8: Aston Villa (a)
11: Leicester City (h)
15: Fulham (h)
23: Wolves (a)