ARSENAL

Gameweek 16 opponents: Aston Villa (A)

Out: Thomas Partey (thigh), Fabio Vieira (groin), Jurrien Timber (knee), Emile Smith Rowe (knee), Takehiro Tomiyasu (calf)

Doubtful: None

Mikel Arteta quotes: "I think everybody is going to be OK.

"We don't know [when Thomas Partey will be back], it's a bit early to get a time frame. If he's back by Christmas then it will be very fast. We're missing key players but we have to continue."

ASTON VILLA

Gameweek 16 opponents: Arsenal (H)

Out: Emiliano Buendia (knee), Tyrone Mings (knee), Bertrand Traore (muscle)

Doubtful: None

Unai Emery quotes: "We had to rest a lot - we played on Sunday and last Thursday as well. The players are at the beginning [of their preparation] so I do not have all the information on some injuries.

"It is going to be very important, the last day [of preparation] and tomorrow for all players to tell me physically and emotionally how they are for tomorrow."

BOURNEMOUTH

Gameweek 16 opponents: Man United (A)

Out: Tyler Adams (thigh), Alex Scott (knee), Ryan Fredericks (calf), Max Aarons (hamstring), Emiliano Marcondes (ankle), Darren Randolph (ill), Lloyd Kelly (muscle), Hamed Traore (ill)

Doubtful: None

Andoni Iraola quotes: "For me, this game is not an easy one to choose a starting XI. When we have played three games in previous weeks, the third one has probably been the worst – Brentford, Arsenal and Manchester City.

"I know we almost won against Brentford but we were not at our best physically. The players have trained well since Palace and everyone looks like they have recovered well. But we have to think because we need to be energetic and fresh.

"We arrived home very late from Palace and, straight away, the next morning you are showing the players videos of United. You have to make them think 'okay, you haven't slept well and you are tired but you have these guys waiting for you in a few hours.

"It's difficult and mentally demanding. The big teams are used it because they play every three or four days when they are in Europe."

BRENTFORD

Gameweek 16 opponents: Sheffield United (A)

Out: Rico Henry (knee), Aaron Hickey (hamstring), Ivan Toney (suspended), Kevin Schade (adductor), Nathan Collins (ankle), Kristoffer Ajer (foot), Bryan Mbeumo (ankle)

Doubtful: Joshua Dasilva (hamstring), Mathias Jensen (adductor)

Thomas Frank quotes: "[The Bryan Mbeumo injury] is bad. He'll have a scan later, but we don't know the exact number of weeks he will be out. He will definitely not play on Saturday [against Sheffield United], and he will be out for weeks. We will know more in the next couple of days.

"[Bryan] must be number two after Ivan [Toney] in terms of goals and assists, which is key. His work rate for the team is incredible; you don't see many wingers who work so hard and mean so much. He's become the key man – 'Give me the ball, I'll take this'. Who will that man be now? We'll find out in the next weeks.

"Football is such a marginal game – inside of the post, outside of the post, deflection – there are so many things that you can't control. And another thing is injuries. We need to do everything we can to recover well, assess and get players back, but there's also just bad luck in it.

"Bryan's injury is a clear one – it's bad luck. He got caught, got pushed and rolled his ankle. It's very frustrating, but I'm a positive guy and we'll find a solution.

"The positive news is that [Mikkel] Damsgaard got minutes [against Brighton] and is looking better and better. [Mathias] Jensen will be a decision I need to make in the next 24 hours, whether I want to push him to be ready or be a little more cautious and have him ready for Villa. I will assess him in the next 24 hours."

BRIGHTON & HOVE ALBION

Gameweek 16 opponents: Burnley (H)

Out: Danny Welbeck (unspecified), Solly March (knee), Julio Enciso (knee), Pervis Estupinan (thigh), Tariq Lamptey (thigh), Ansu Fati (thigh), Adam Webster (knock)

Doubtful: None

Roberto De Zerbi quotes: "[Adam] Webster is still unavailable to play. I don't know when he will play.

"But it's important for us that [Lewis] Dunk and Mo [Dahoud] are available because they're both very important, especially in this moment. We are going through a difficult moment in terms of injuries and having two players available is important.

"The news about Ansu Fati is that he needs three months from the injury. It's bad news for us because he was playing better, he was understanding better the idea. I am sorry for him and the team especially now when Welbeck is not playing, Enciso is not playing."

BURNLEY

Gameweek 16 opponents: Brighton (A)

Out: Lyle Foster (mental health), Luca Koleosho (knee), Jack Cork (calf)

Doubtful: Josh Cullen (knock)

Vincent Kompany quotes: "It's bad news for us, [Koleosho]'s going to be out for a while apparently. I can't really share the medical details but it appears in the collision he did something to his knee.

"We think he's going to be long-term fine, but short-term we have to give him the time to recover.

"We will do everything we can to make sure he will get back healthy and ready to go again. The key concern now is to make sure he doesn't sustain any long-term damage because he's still young, so we're going to do everything that is right by him."

CHELSEA

Gameweek 16 opponents: Everton (A)

Out: Wesley Fofana (knee), Ben Chilwell (thigh), Trevoh Chalobah (thigh), Carney Chukwuemeka (knee), Lesley Ugochukwu (unspecified)

Doubtful: Christopher Nkunku (knee), Romeo Lavia (ankle), Malo Gusto (tendon), Noni Madueke (unspecified)

Mauricio Pochettino quotes: "We are still assessing [Nkunku] day-by-day. I don't believe that he will be involved [against Everton] but we need to assess day-by-day.

"I think we are trying to optimise the players we have and then we need to be calm because when you suffering these types of things it's about being calm.

I am disappointed because we wanted to win against Manchester United and I think we were close. Of course they started really good, they showed more energy than us. They were more clinical. It's about dealing with the situation, we can't complain and have to face the reality.

"It's a little thing that's part of a component. It's the composition of the squad, we need to find a good balance on the pitch and the inconsistency came from a different part of the team. The challenge was to settle everything and to behave like a team. For different circumstances we are a little late."

CRYSTAL PALACE

Gameweek 16 opponents: Liverpool (H)

Out: Jesurun Rak-Sakyi (thigh), Dean Henderson (thigh), Eberechi Eze (ankle), Cheick Doucoure (Achilles), Rob Holding (ankle), Tyrick Mitchell (hip)

Doubtful: None

Roy Hodgson quotes: "[Tyrick Mitchell] is injured, so he is another one that we have lost but that we're ill-equipped to lose in this moment in time with [Cheick] Doucoure and [Ebere] Eze still out of the team.

"Our injury list isn't enormously long, it's just that three of the players we are missing are three regular players in the team.

"Mitchell was a hip injury which came as a result of a contusion which has provoked a hip injury. This game was definitely too quick coming around for him to be considered, but that doesn't mean that he won't be considered for the next game."

EVERTON

Gameweek 16 opponents: Chelsea (H)

Out: Dele Alli (groin)

Doubtful: Amadou Onana (calf), Andre Gomes (calf), James Garner (illness), Jordan Pickford (knee), Seamus Coleman (knock)

Sean Dyche quotes: "Jimmy [Garner], I hope [will be available]. It's a sickness bug and you never know, they can pass very quickly but there are some longer ones. We hope it's a 24-hour situation, so he'd have time to get food back in himself and feel stronger again.

"Amadou [Onana], we're hoping will be around it – possibly in the squad. We'll just have to wait and see how the next couple of days of training go.

"We'll check on Seamus tomorrow. He has a minor situation, we think, which is unfortunate but that can happen. He has been out a long time. It's great to have him back, he wore the armband with pride like he does.

"[Pickford] has just got a niggly thing on his knee. I'll find out more tomorrow, you never like to talk about it until you find out 24 to 48 hours later. I don't think it's anything too serious."

FULHAM

Gameweek 16 opponents: West Ham (H)

Out: Issa Diop (ankle), Tyrese Francois (unspecified)

Doubtful: Rodrigo Munoz (knee), Adama Traore (hamstring)

Marco Silva quotes: "Adama Traore and Rodrigo Muniz are much closer to returning. After tomorrow's session, I'll take a decision on them both."

LIVERPOOL

Gameweek 16 opponents: Crystal Palace (A)

Out: Thiago Alcantara (hip), Stefan Bajcetic (calf), Andrew Robertson (shoulder), Diogo Jota (leg), Joel Matip (ankle)

Doubtful: Alisson Becker (hamstring), Alexis Mac Allister (knee)

Jurgen Klopp quotes: "Alisson is back in training from Thursday, he trained normally. He's doing well, but I don't know about him being ready for tomorrow.

"[Alexis Mac Allister] doesn't look good. We'll have to see day by day. They were hopeful after the game that it was not that serious, but in this period of the year you're out for five days and that's 12 games. I don't expect him to be ready for tomorrow.

"We have known for four or five days Joel will be out for a long time. We have four centre-backs already. That's alright. If we had five in already, that's a completely different team dynamic with one not involved.

"If we can go with those four, great, if not then it will be a bit more tricky. Unless other clubs put a world-class centre-back under the Christmas tree for us, I don't think so to be honest."

LUTON TOWN

Gameweek 16 opponents: Man City (H)

Out: Mads Andersen (hamstring), Dan Potts (hamstring), Reece Burke (hamstring), Issa Kabore (ineligible)

Doubtful: Cauley Woodrow (calf), Tom Lockyer (back), Albert Sambi Lokonga (hamstring), Marvelous Nakamba (knee), Chiedozie Ogbene (hamstring)

Rob Edwards quotes: "We're hoping that Tom Lockyer will be back available which is great news. Issa Kabore is not eligible as it is his parent club. Reece Burke is very, very close and Mads Andersen is progressing well and is very close to full training.

"[Lokonga]'s been out for a long time, so we need to be sensitive how we integrate him back into things."

MANCHESTER CITY

Gameweek 16 opponents: Luton (A)

Out: Kevin De Bruyne (hamstring)

Doubtful: Jeremy Doku (muscle)

Pep Guardiola quotes: "I think [De Bruyne] has started to run on the pitch but hasn't trained with us once. The FIFA Club World Cup is in two or three weeks. I don't know. Maybe it's a bit early but I don't know (at this point).

"Kevin is so important. But unfortunately, he's had a tough injury for three or four months. Don't put pressure on him, when he's back we'll have open arms for him.

"But I've said to the team, do you know how we struggled to get the Treble? We were eight or nine points behind Arsenal. With all the problems and injuries we had. It's normal, that's why we gave credit to the Treble.

"The same team right now, before the game against Wolves, were one game off the best start ever for this club. At the international break we were top. We faced Chelsea, Liverpool, Tottenham, Aston Villa, they're top teams, and it can happen.

"We didn't deserve to win against Villa, I don't need time to reflect. I don't need 'oh maybe we can do this'. We have to do it all together and if Kevin is here, yes, if not, okay.

"Or maybe Rodri's not here, so I have to find a way when he's not there. Last season he was almost always there so I have to find a way."

MANCHESTER UNITED

Gameweek 16 opponents: Bournemouth (H)

Out: Casemiro (hamstring), Lisandro Martinez (foot), Christian Eriksen (knee), Jadon Sancho (banished), Amad Diallo (knee), Tyrell Malacia (knee), Victor Lindelof (knock)

Doubtful: Raphael Varane (back), Mason Mount (calf)

Club statement: "United have been boosted by the return of Raphael Varane, who is fit to play again after missing our Blues victory due to a sore back. The France international trained at Carrington on Thursday, with our cameras in attendance.

"Ten Hag has, however, lost the services of Victor Lindelof, who is out for Saturday's game. Our no.2 left the field at half time on Wednesday, and was replaced by Sergio Reguilon, with Luke Shaw shifting inside to centre-back.

"Shaw has played next to Maguire during each of the last two games but Jonny Evans could slot in there after returning from injury as a late substitute in midweek.

"Amad was pictured in training on Thursday as he steps us his recovery from a long-term setback, which has kept him out since July.

"Christian Eriksen and Mason Mount have been on the treatment table recently, while Casemiro, Tyrell Malacia and Lisandro Martinez are not expected to feature this side of Christmas."

NEWCASTLE UNITED

Gameweek 16 opponents: Spurs (A)

Out: Sandro Tonali (suspended), Sven Botman (knee), Callum Wilson (hamstring), Matt Targett (hamstring), Dan Burn (back), Elliot Anderson (back), Harvey Barnes (foot), Jacob Murphy (shoulder), Javi Manquillo (groin), Joe Willock (Achilles), Sean Longstaff (ankle), Nick Pope (shoulder)

Doubtful: Jamaal Lascelles (groin)

Eddie Howe quotes: "Our squad is stretched and I've said that many times. The same XI are having to go again and again and they've done well for us.

"Ideally, [during Thursday's 3-0 defeat at Everton] I'd have been looking to the bench to freshen us up, but those options weren't there. I have to compliment the players who have played but mentally we weren't at our best.

"We're used to the rhythm of playing and resting, then playing again but we desperately need help, we desperately need those injured players back.

"The amount of injuries has been concerning for us because the ability to rotate and make changes hasn't been there. So then you have the risk of fatigued players. That's not an excuse, it's just reality and we're having to deal with that."

NOTTINGHAM FOREST

Gameweek 16 opponents: Wolves (A)

Out: Taiwo Awoniyi (groin), Willy Boly (knock)

Doubtful: None

Steve Cooper quotes: "When we come together later, we will have to look at the failings of last night. When we - and I'm talking about all of us - see where we fell short last night, you can deal with it in a couple of ways; you can blame someone else or you can take responsibility for it yourself and aim to do better. We need to make sure we do the latter.

"We've all got to take collective, individual responsibility and say 'I need to do better than that'. That's where the start of putting last night right starts."

SHEFFIELD UNITED

Gameweek 16 opponents: Brentford (H)

Out: Chris Basham (foot), Rhian Brewster (knee), Rhys Norrington-Davies (thigh), John Egan (ankle), Tom Davies (thigh), Daniel Jebbison (illness), Oliver McBurnie (suspended)

Doubtful: George Baldock (hamstring)

Chris Wilder quotes: "We need to have a bit more control when we have possession and if we do that, hopefully we can show our quality going the other way. I just don't want to be sat on the edge of the box waiting to get beat.

"The approach of the team was good, we got up the pitch and asked questions. I've got an awful lot of respect for Jurgen [Klopp] and his team, and I think they will have felt they'd been in a game on Wednesday. Anybody who watched it will have said there's fight and life in Sheffield United still."

TOTTENHAM HOTSPUR

Gameweek 16 opponents: Newcastle (H)

Out: Ivan Perisic (knee), Micky van de Ven (hamstring), James Maddison (ankle), Ryan Sessegnon (hamstring), Manor Solomon (knee), Alfie Whiteman (ankle), Ashley Phillips (ankle), Rodrigo Bentancur (ankle), Eric Dier (groin)

Doubtful: Son Heung-min (back)

Ange Postecoglou quotes: "The last update I got [on Son] was late last night. He was a bit sore after the game, obviously. We'll see how he recovers today. There were a couple of others with knocks but I don't think anything significant."

"I think that's it [until the new year]. We got Pape [Sarr] a few minutes last night and I understand him and Richy [Richarlison] reported they were OK but there won't be anyone else coming back between now and the New Year."

WEST HAM UNITED

Gameweek 16 opponents: Fulham (A)

Out: Michail Antonio (knee)

Doubtful: Alphonse Areola (wrist)

David Moyes quotes: "No team news to give out. We're reporting in so early, so we're waiting for them to check in and we'll find out in the next few hours."

WOLVERHAMPTON WANDERERS

Gameweek 16 opponents: Nottingham Forest (H)

Out: Pedro Neto (hamstring), Joe Hodge (shoulder), Jonny (banished)

Doubtful: Jose Sa (back), Rayan Ait Nouri (ankle)

Gary O'Neil quotes: "Pedro [Neto] is still working with the fitness coach. He is upping the level of intensity of what he can do. One more week with the coach and then come back to join us for training – will hopefully then be available.

"Rayan [Ait-Nouri]'s ankle is still sore, he's not progressed as quickly as we'd hoped. He didn't manage to train yesterday and only did a little bit today. We will asses him in the morning, but it is likely he won't be available.

"I have a decision to make - not one I ever envisaged when I came in. We seemed to have a clear one and two when I arrived. Whoever plays tomorrow, what Dan [Bentley] has done in the last few weeks has proved that he can push.

"It puts him and the club in a good spot. Jose knows the level needs to be high, as does Dan. The news won't be easy to deliver to the one who misses out."