Manchester United may reportedly be without centre-back pair Harry Maguire and Victor Lindelof for Saturday's Premier League meeting with West Bromwich Albion.
The Red Devils welcome lowly West Brom to Old Trafford seeking successive league wins for the first time this season, having defeated Everton 3-1 before the international break.
However, ESPN claims that Ole Gunnar Solskjaer is facing a defensive crisis of sorts as Maguire and Lindelof are major doubts.
Maguire played the full 90 minutes of England's 4-0 win over Iceland on Wednesday but is said to have bruised his foot, while Lindelof was forced off in the second half of Sweden's 4-2 loss to France with a back problem.
Axel Tuanzebe and Eric Bailly are on standby to fill in against Albion, though both have struggled with niggling issues of their own and are far from fully fit.
Left-back Luke Shaw has been ruled out until next month, meanwhile, and Alex Telles must return a second negative coronavirus test before he can be considered for selection.
