Here, Sports Mole rounds up all of the latest team news for both sides ahead of the midweek showdown.
Out: James McArthur (unspecified), Connor Wickham (unspecified), Wilfried Zaha (thigh), Jeffrey Schlupp (thigh), Mamadou Sakho (thigh), Wayne Hennessey (unspecified), Nathan Ferguson (thigh), James Tomkins (eye), Nathaniel Clyne (muscle)
Sports Mole's predicted XI: Guaita; Ward, Kouyate, Cahill, Van Aanholt; Milivojevic, Riedewald; Townsend, Eze, Ayew; Mateta
Doubtful: Edinson Cavani (muscle)
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Bailly, Maguire, Telles; Matic, Fred; James, Fernandes, Rashford; Martial
Watch the Sports Mole Football Shorts prediction for this game below: