United appear set to follow the lead of Premier League champions Liverpool, who will not allow players to travel to international matches in March if they have to quarantine on their return.
Jurgen Klopp confirmed on Wednesday they would make the most of FIFA giving clubs the option to prevent players who may be affected by the regulations from joining up with their countries.
Palace boss Roy Hodgson said: "Yes it's a concern because the injury which kept him out was an injury in the groin region and he felt it again.
"It is a major concern and if it turns out he can't play in the next couple of games, it will be a major blow for us because I thought he did very well in the 60 minutes he played.
"He is a player we would like to see available but he is another in the course of the season who has missed a lot of games for injury or personal reasons."