Manchester United manager Louis van Gaal could hand a debut to four of his summer recruits as his team look to register their first win of the season.
Daley Blind and Radamel Falcao are available after signing on the final day of the transfer window, Marcos Rojo has been granted a work permit and Luke Shaw is fit enough to feature for part of the fixture at Old Trafford.
However, Phil Jones is absent after being ruled out for a month with a hamstring injury, while Chris Smalling and Ashley Young also miss out.
Queens Park Rangers boss Harry Redknapp could be without Joey Barton after the midfielder suffered a minor injury in training.
That could see Redknapp hand a debut to Sandro, who has been brought in from Tottenham Hotspur, while Niko Kranjcar is expected to be in the matchday squad.
Defender Rio Ferdinand, who left Manchester United to join QPR in the summer, will start at centre-back.
Recent form
Manchester United: LDLD
Queens Park Rangers: LLLW
Possible starting lineups
Manchester United: De Gea; Rojo, Blind, Evans; Di Maria, Fletcher, Shaw, Valencia, Mata; Van Persie, Rooney
Queens Park Rangers: Green; Caulker, Hill, Isla, Ferdinand; Phillips, Mutch, Hoilett, Sandro, Fer; Austin
Sports Mole says: 4-1
