West Ham vs. Newcastle (Wednesday, 8.00pm)
Fresh from dispatching top-four foes Manchester United in front of a passionate home crowd, Newcastle United will continue their quest for Champions League football when they face West Ham United at the London Stadium on Wednesday evening.
The Hammers also picked up a vital win last time out, defeating relegation rivals Southampton to move one point clear of the bottom three, but David Moyes's men still have plenty of work to do in order to avoid the drop.
We say: West Ham United 0-1 Newcastle United
Although West Ham have upped their game of late – avoiding defeat in each of their last five home league matches – high-flying Newcastle look set to notch a fourth consecutive victory as they continue their top-four charge on Wednesday.
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Man Utd vs. Brentford (Wednesday, 8.00pm)
Aiming to snap a three-game run without a win or goal in the Premier League, Manchester United welcome Brentford to Old Trafford on Wednesday evening.
The Red Devils were comprehensively beaten 2-0 by Newcastle United at the weekend, while the Bees were pegged back three times in a 3-3 thriller with Brighton & Hove Albion.
We say: Manchester United 2-2 Brentford
Brentford tend to thrive when the going gets tough against Big Six clubs, and Frank's side ought to ask several questions of the Man United backline, especially with a day's extra rest to enjoy.
Ten Hag should get an immediate response from his side after the weekend's hardship, but with Brentford seldom suffering defeat themselves and establishing themselves as stalemate specialists - taking one point from a league-high 13 games this season - we can envisage an entertaining draw at Old Trafford; a marked improvement from their four-goal defeat in August for the hosts.
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> How Man United could line up against Brentford
> Man United injury, suspension list vs. Brentford body check tags ::
