Manchester United boss Sir Alex Ferguson has left out striker Robin van Persie for his side's Premier League clash with West Bromwich Albion.
Van Persie drops to the bench despite Wayne Rooney also being unavailable for the Red Devils. Javier Hernandez also loses his starting place as Shinji Kagawa and Danny Welbeck return to the side.
The attacking duo are two of five changes made by Ferguson, who also brings in Nemanja Vidic, Tom Cleverley and Ashley Young in place of Rio Ferdinand, Paul Scholes and Ryan Giggs.
West Brom have also made a host of changes, bringing in seven new faces from their 2-1 victory at Queens Park Rangers.
Gabriel Tamas, Liam Ridgewell, George Thorne, Markus Rosenberg, Graeme Dorrans, Peter Odemwingie and Shane Long all come into the starting XI for the Baggies.
Man Utd: De Gea; Smalling, Vidic, Evans, Evra; Valencia, Carrick, Cleverley, Young; Kagawa, Welbeck
Subs: Lindegaard, Ferdinand, Giggs, Hernandez, van Persie, Scholes, Buttner
West Brom: Foster; Jones, McAuley, Tamas, Ridgewell; Thorne, Brunt; Rosenberg, Dorrans, Odemwingie; Long
Subs: Myhill, Lukaku, Morrison, Jara Reyes, Fortune, Dawson, El Ghanassy
