Manchester United teenager Omari Forson will make his full Premier League debut in this afternoon's encounter against Fulham at Old Trafford.
In the absence of the injured Rasmus Hojlund, manager Erik ten Hag has turned to 19-year-old Forson to join Marcus Rashford, Bruno Fernandes and Alejandro Garnacho in attack.
Academy graduate Forson steps up to start his first senior match and make just his second top-flight appearance, three-and-a-half weeks after coming on as a late substitute against Wolverhampton Wanderers.
Ten Hag has made just two changes to the Red Devils side that beat Luton Town 2-1 last weekend, with the only other alteration being the return of Victor Lindelof, who replaces the injured Luke Shaw at left-back.
Harry Maguire and Raphael Varane retain their places in the heart of the defence, protecting Andre Onana between the sticks, as Diogo Dalot continues to operate at right-back, while Kobbie Mainoo and Casemiro link arms once again in centre-midfield.
As for Fulham, Marco Silva has made a total of six changes to the lineup that began the 2-1 defeat at home to Aston Villa last time out, with Issa Diop, Tim Ream, Tom Cairney, Joao Palhinha, Bobby De Cordova-Reid and Willian all making way.
Ex-Manchester City youngster Tosin Adarabioyo and Calvin Bassey are both recalled to start at centre-back at the expense of Diop and Ream, joining Timothy Castagne and Antonee Robinson in the back four.
Palhinha, who is serving a two-match suspension due to an accumulation of yellow cards, and Cairney are both replaced in midfield by Harrison Reed – captaining the Cottagers – and Sasa Lukic.
In attack, former Man United man Andreas Pereira and in-form striker Rodrigo Muniz retain their places, but both Harry Wilson and Alex Iwobi come in for De Cordova-Reid and Willian to presumably play on the flanks.
Manchester United: Onana; Dalot, Varane, Maguire, Lindelof; Casemiro, Mainoo; Garnacho, Fernandes, Forson; Rashford
Subs: Bayindir, Evans, Kambwala, McTominay, Amrabat, Collyer, Eriksen, Amad, Antony
Fulham: Leno; Castagne, Tosin, Bassey, Robinson; Reed, Lukic; Wilson, Pereira, Iwobi; Muniz
Subs: Rodak, Ream, Diop, Tete, Bello-Toure, Cairney, De Cordova-Reid, Traore, Broja