Montreal vs. Vancouver (Saturday, 8.00pm)
After beginning the campaign with three straight defeats, Montreal have captured two in a row domestically, defeating the New York Red Bulls 2-1 last Saturday, while the Caps have the second-worst record in the league following a 3-2 loss at home to the Portland Timbers.
We say: CF Montreal 1-0 Vancouver Whitecaps
Earthquakes vs. Nashville (Saturday, 8.30pm)
On the other hand, the away side set out to record a third consecutive victory and continue their surge up the league table.
We say: San Jose Earthquakes 1-2 Nashville SC
Atlanta vs. Cincinnati (Saturday, 11.00pm)
A pair of Eastern Conference teams coming off narrow defeats in their previous games will resume their Major League Soccer campaigns on Saturday as FC Cincinnati battle Atlanta United at Mercedes-Benz Stadium.
The Five Stripes saw their three-game winning streak snapped last week, losing 1-0 to Charlotte FC, while the Orange and Blue had the week off after beginning this month with a 4-3 defeat at home to CF Montreal.
We say: Atlanta United 3-2 FC Cincinnati
Houston vs. Portland (Saturday, 11.00pm)
Houston Dynamo play host to Portland Timbers at the PNC Stadium on Saturday aiming to pick up a third consecutive victory.
Meanwhile, the away side also come into the clash with the wind in their sails having ended a three-game winless run last time out.
We say: Houston Dynamo 1-1 Portland Timbers
NY Red Bulls vs. Dallas (Sunday, 12.00am)
Unbeaten in their last four outings, Dallas travel to the Red Bull Arena to face off against the New York Red Bulls on Sunday.
Meanwhile, the hosts are still searching for their first home win of the campaign and will be looking to finally break the duck at the fourth time of asking.
We say: New York Red Bulls 2-1 Dallas
Columbus Crew vs. Orlando City (Sunday, 12.30am)
The Lions sit second in the Eastern Conference after seven matches, while their hosts have suffered back-to-back defeats after making an impressive start of their own.
We say: Columbus Crew 1-2 Orlando City
Given their slightly stronger start and a squad packed with talent, we back Orlando City to take all three points at the weekend.
DC United vs. Austin (Sunday, 12.30am)
The visitors sit fourth in the Western Conference after six games, with their hosts having earned six points from their opening five games.
We say: DC United 0-1 Austin FC
New England vs. Charlotte FC (Sunday, 12.30am)
New England Revolution enter Sunday's clash with Charlotte FC in poor form, having lost their last five consecutive games in all competitions, which has left them in 13th spot in the Eastern Conference.
This weekend's visitors to the Gillette Stadium have began their new era in the MLS well, currently sitting fifth in the table after picking up nine points from their first seven games.
We say: New England Revolution 0-1 Charlotte FC
Charlotte may have lost all three of their away game so far this season, but with New England in poor form ahead of this encounter, the visitors should fancy their chances of collecting maximum points.
The hosts are likely to make the game tight as their on home soil, but their confidence must be very low at the moment which could be a decisive factor in this weekend's result.
Toronto vs. Philadelphia (Sunday, 12.30am)
The Reds come into this contest unbeaten in their previous three Major League Soccer encounters, while Philly are the only team in the league who have yet to lose, winning five in a row.
We say: Toronto 0-1 Philadelphia Union
Chicago Fire vs. LA Galaxy (Sunday, 1.00am)
This weekend's hosts suffered their first defeat of the campaign in their previous outing, while LA Galaxy enter this encounter after bouncing back from consecutive losses with two wins on the bounce.
We say: Chicago Fire 1-2 Los Angeles Galaxy
This is expected to be an entertaining encounter after both sides have started the season quite well, but entering this match on the back of a derby win could be the boost that Galaxy need in this away fixture.
Chicago have not scored a flurry of goals this season, which will play into the hands of Galaxy, who can then use the hosts' lack of attacking threat to make sure they outscore their opponents.
Minnesota Utd vs. Colorado (Sunday, 1.00am)
Sunday's hosts, Minnesota, enter this encounter on the back of consecutive defeats, while the Rapids are aiming to avoid back-to-back losses after their four-game unbeaten run was ended last time out.
We say: Minnesota United 1-1 Colorado Rapids
Both of these teams are looking to get back to winning ways but having started the campaign in a similar fashion, this weekend's contest is likely to end all square.
Neither team have scored many goals in recent weeks, which is why this match could be a low-scoring draw, but both sides are expected to concede also.
Seattle vs. Inter Miami (Sunday, 3.00am)
Last weekend, an outstanding individual performance gave the Herons their first victory of the regular season, 3-2 over the New England Revolution, while Seattle advanced to the final of the CONCACAF Champions League (CCL) on Wednesday, defeating New York City FC 4-2 on aggregate.