The visitors have been struggling themselves all season, with their 15-point haul leaving them at the foot of the Championship table.
A 2-0 victory over Luton Town in midweek saw QPR pick up their first three points since late November, when they defeated Rotherham United.
Their struggles in the first half of the campaign have left the Loftus Road outfit hovering above the drop zone, just five points from safety.
Warburton's men will be seeing the weekend's encounter as a perfect opportunity to put some daylight between themselves and the bottom three, and the result could be crucial for both teams' prospects for the rest of the season.
Despite Wycombe currently occupying last place in the second tier of English football, the Chairboys have hit some good form of late.
A convincing 4-1 victory over Preston North End in the FA Cup in their most recent fixture made it two wins from three games and should give Gareth Ainsworth's side confidence coming into this one.
Scoring goals has been the biggest issue for the newly-promoted side. Just 16 efforts in their 23 league games means they have the joint-third lowest tally in the division and has heavily contributed to their struggles.
Three points at the weekend could potentially see Wycombe leapfrog Rotherham in the league standings and spark fresh hope that they could pull off a huge shock and stave off relegation.
Queens Park Rangers Championship form: LDDLDW
Queens Park Rangers form (all competitions): DDLDLW
Wycombe Wanderers Championship form: LLDLWL
Wycombe Wanderers form (all competitions): LDLWLW
Austin made an instant impact on his return to the club and should be in line for his first start at Loftus Road in his second spell with the West London outfit.
Whether Macauley Bonne is rewarded for his late goal against Luton or not will be the big decision that Warburton has to make.
The striker scored his third goal of the season against the Hatters and will be hoping to feature from the first whistle at the weekend.
Ainsworth rested several first-team players for their FA Cup victory last time out and now faces a dilemma whether to restore them to the starting XI following their impressive performance against Preston or stick with the same side.
Queens Park Rangers possible starting lineup:
Dieng; Osayi-Samuel, Barbet, Cameron, Dickie, Kane; Carroll, Chair, Ball; Austin, Bonne
Wycombe Wanderers possible starting lineup:
Allsop; McCarthy, Knight, Tafazolli, Jacobson; Wheeler, Adeniran, Bloomfield; Muskwe, Ikpeazu, Onyedinma
We say: Queens Park Rangers 2-1 Wycombe Wanderers
Despite Wycombe's lowly position, they always put up a good fight and very rarely concede more than two goals. QPR will have to be at their very best to beat them, but after their win last time out and the return of Austin providing a boost to the whole club, we fancy them to put back-to-back wins together for the first time since early November.