Reading manager Steve Clarke has shuffled his pack for the visit of Reading, with Alex Pearce, Oliver Norwood, Danny Williams and Hal Robson-Kanu all coming into the side.
Jem Karacan, Jake Cooper, Nathan Ake and Nick Blackman are the four that make way, while Pavel Pogrebnyak is still carrying a knock from the FA Cup semi-final defeat.
Brentford are without on-loan Everton youngster Chris Long, who has a knee injury, while Lewis Macleod is not yet ready to return from his hamstring problem.
Mark Warburton is also without forward Scott Hogan for the must-win encounter.
Reading: Federici; Gunter, Pearce, Hector, Obita; Chalobah, Norwood, Williams; McCleary, Mackie, Robson-Kanu.
Brentford: Button; Odubajo, Dean, Tarkowski, Bidwell; Jota, Douglas, Diagouraga, Judge, Pritchard; Gray.
