Gareth Bale will reportedly miss Real Madrid's Champions League quarter-final second leg against Bayern Munich.
The Welshman sustained a calf injury in the first leg of the last-eight clash - which Madrid won 2-1 - and missed his team's 3-2 victory over Sporting Gijon in La Liga at the weekend.
Real had hoped to have the former Tottenham Hotspur attacker available for the European tie at the Bernabeu, but according to Marca, the calf problem will keep Bale on the sidelines.
As a result, Isco, who scored twice against Sporting Gijon at the weekend, is expected to start alongside Karim Benzema and Cristiano Ronaldo in the final third of the field.
Real Madrid are bidding to become the first team in the modern era to successfully defend the Champions League.
