The 23-year-old sustained the muscle problem in training and will now miss the European showpiece in Milan, which pits Real against local rivals Atletico Madrid for the second time in the last two seasons.

The injury also puts Varane's hopes of representing France at Euro 2016 in jeopardy, with the host nation getting their campaign underway on June 10.

"After tests carried out today on the player Raphael Varane he has been diagnosed with a grade two injury in the left thigh muscle. His recovery will continue to be assessed," read a statement on the official Madrid website.

Varane has made 33 appearances in all competitions for Madrid this season.

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Premier League Table

	Team	P	W	D	L	F	A	GD	PTS
1	Barcelona	12	11	0	1	40	11	29	33
2	Real Madrid	11	7	3	1	21	11	10	24
3	Atletico Madrid Atletico	12	6	5	1	18	7	11	23
4	Villarreal	11	6	3	2	20	19	1	21
5	Osasuna	12	6	3	3	17	16	1	21
6	Athletic Bilbao	12	5	4	3	18	12	6	19
7	Real Betis Betis	12	5	4	3	12	10	2	19
8	Mallorca	12	5	3	4	10	9	1	18
9	Rayo Vallecano	11	4	4	3	12	10	2	16
10	Celta Vigo	12	5	1	6	18	20	-2	16
11	Real Sociedad	12	4	3	5	10	10	0	15
12	Girona Girona	12	4	3	5	15	17	-2	15
13	Sevilla	12	4	3	5	12	17	-5	15
14	Alaves Alaves	12	4	1	7	14	19	-5	13
15	Leganes	12	2	5	5	12	16	-4	11
16	Getafe	12	1	7	4	8	10	-2	10
17	Espanyol	12	3	1	8	11	22	-11	10
18	Las Palmas Las Palmas	12	2	3	7	13	21	-8	9
19	Real Valladolid Valladolid	12	2	2	8	9	24	-15	8
20	Valencia	11	1	4	6	8	17	-9	7