Hazard has been plagued by injuries since joining Madrid from Chelsea last summer, being limited to only 22 appearances across all competitions during his debut season.
The winger is yet to feature this term due to a muscle problem, suffering a setback the day before he was scheduled to return which has subsequently ruled him out of the last three games.
The Daily Mail reports that Hazard will now be sidelined until at least after the November international break, an absence which would see him miss a minimum of six more games.
That would include the opening Clasico of the season against Barcelona, in addition in La Liga games against Huesca and Valencia and Champions League meetings with Shakhtar Donetsk, Borussia Monchengladbach and Inter Milan.
Hazard has scored just one goal in his 22 outings for Los Blancos so far.