Real Betis vs. Levante (Sunday, 1.00pm)
A poor start to the season has left the visitors at the foot of the La Liga table, while their hosts maintained their position in fifth thanks to a win last time out.
We say: Real Betis 1-0 Levante
While Levante will be encouraged by their performance last time out, they face a particularly tough test on Sunday, and we expect them to fall just short.
Espanyol vs. Real Sociedad (Sunday, 3.15pm)
Imanol Alguacil's men dropped off the summit after a draw with Valencia, but they remain just one point behind league leaders Real Madrid, while their visitors sit 10th in the Spanish top flight.
We say: Espanyol 1-2 Real Sociedad
Espanyol will certainly not roll over on Sunday, having proved themselves to be tough to beat, but we see the visitors having the quality to come out with a hard-fought three-point haul.
Cadiz vs. Atletico (Sunday, 5.30pm)
Diego Simeone's men suffered a harmful defeat to AC Milan in the Champions League last time out, but they made a return to winning ways in their most recent league game, while the hosts were thrashed by fellow strugglers Getafe on Sunday.
We say: Cadiz 0-2 Atletico Madrid
Given Cadiz's struggles this term, we back the defending champions to pick up a relatively routine victory on Sunday.
Real Madrid vs. Sevilla (Sunday, 8.00pm)
Real Madrid are currently one point clear of second-placed Real Sociedad at the summit, while Sevilla are only two points behind Carlo Ancelotti's side ahead of this weekend's mouthwatering contest.