Lille coach Rene Girard has handed another start to Belgian centre-forward Divock Origi following his match-winning goal against Lorient.
Ronny Rodelin will start alongside the 18-year-old, with Florent Balmont, Idrissa Gueye, Marvin Martin and Antonio Mavuba forming a four-man midfield.
Gaeten Courtet and Eliran Atar will be looking to get among the goals for the hosts, who suffered a 2-1 defeat to Rennes on the opening day.
Reims: Agassa, Mandi, Weber, Tacalfred, Glombard, Krychowiak, Oniangue, Fortes, Albaek, Courtet, Atar
Lille: Enyeama, Kjaer, Beria, Souare, Basa, Balmont, Gueye, Martin, Mavuba, Rodelin, Origi