The Millers are six points below the dotted line, but they have three games in hand and have to make the first of those count against a QPR side still not entirely out of the playoff picture.
United were further frustrated in their survival quest on Saturday as they played out a goalless draw with fellow strugglers Huddersfield Town.
Paul Warne's men have won just two of their last 11 league games, losing eight of those, and they still have some difficult games to come.
Tuesday's visit of QPR is the first of four successive home matches, though, including games against Coventry City and Birmingham City, who are very much in the relegation picture.
Having lost five games in a row at the New York Stadium, it goes without saying that Warne's side quite simply need to get out of their slump if they are to dodge the drop.
Scoring goals home and away has also been a big issue, the Millers having failed to find the net in seven of their last 10 league games, including in each of their last three.
QPR have had far fewer problems scoring, failing to do so just once in their last 10, but they have recorded back-to-back wins just once since February.
That is something Mark Warburton will be looking to put right in midweek on the back of his side's comfortable 4-1 win over Sheffield Wednesday.
QPR have now won seven of their last nine home league games, but it is just one win in five on their travels, most recently losing 3-1 at Nottingham Forest.
However, since the turn of the year, only Watford and Norwich (both 14) have won more Championship games than QPR's 11, the Rs already equalling their total of league wins in 2020.
With another victory here, combined with other results going their way, the West London side may just find themselves in the playoff mix once again.
As for the visiting side, they remain without striker Charlie Austin after he was hit with a three-game ban by the Football Association for violent conduct versus Forest.
That will not bother Warburton too much given Dykes's form, with Ilias Chair and Willock positioned just off the Scotland international.
Rotherham United possible starting lineup:
Johansson; Ihiekwe, Wood, MacDonald; Olosunde, Lindsay, Wing, Wiles, Harding; Crooks, Smith
Queens Park Rangers possible starting lineup:
Dieng; Dickie, De Wijs, Barbet; Kakay, Johansen, Field, Wallace; Willock, Chair; Dykes
We say: Rotherham United 0-1 Queens Park Rangers
QPR have been the third best side in the Championship in terms of form this calendar year, but they do not have the best of away records.
Rotherham have lost five in a row on their own patch, though, so this is a good opportunity for Warburton's men to put another win on the board and climb the division.
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