AC Milan can edge closer to this weekend's opponents Sampdoria in the Seria A table if they clinch a victory on away turf.
In contrast, Sampdoria can move within the top two title challengers Juventus and Roma should they come out on top on Saturday.
Sampdoria currently occupy fourth spot in the league standings, while Milan reside three places below on 16 points compared to their rivals who have 19.
The hosts have only suffered one defeat in the league in 10 fixtures, which came in the form of a 1-0 loss to Inter Milan last month.
Milan had an impressive six-game unbeaten run in the league, but it came crashing down last weekend when Palermo grabbed a 2-0 victory on their opponents' home turf.
Milan have the edge over Sampdoria in their recent head-to-heads having won two, drawn one and lost one in their last four meetings.
In order to get back on track, Fernando Torres and Jeremy Menez are likely to provide the attacking threat for the visitors.
Recent form
Sampdoria: WLDDWW
AC Milan: LDDWWD
Possible starting lineups
Sampdoria: Romero; Cacciatore, Palombo, Regini; Soriano, L Rizzo, Obiang, De Silvestri, Mesbah; Bergessio, Okaka
AC Milan: Lopez; Rami, Alex, De Sciglio, Abate; De Jong, Poli, Honda; Saponara, Menez, Torres
Sports Mole says: 1-1