Sampdoria have hammered fellow relegation candidates Pescara 6-0 at home in Serie A, thanks to four goals from Mauro Icardi.
The hosts opened the scoring the half-hour mark from the penalty spot through Eder.
Cristian Terlizzi pulled Daniele Gastaldello's shirt inside his own area, and Eder made no mistake from 12 yards.
Icardi doubled his side's advantage three minutes before the half-time interval when he smashed home after being sent through by Pedro Obiang.
Obiang himself etched his name on the scoresheet five minutes into the second half with a curling finish for his first Serie A goal.
Icardi made it 4-0 to the Genoa outfit just six minutes later and completed his hat-trick on the hour mark with a simple tap-in from Eder's pass.
The 19-year-old striker scored his fourth goal of the afternoon in the 72nd minute with an accurate angled drive.