Racing vs. Sao Paulo (Wednesday, 11.00pm)
While the visitors currently sit in top spot without conceding a goal, Racing Club will move ahead of the Brazilian outfit with victory at Estadio Presidente Peron.
We say: Racing Club 1-1 Sao Paulo
Already holding an advantage over third place, both teams may prioritise avoiding defeat on Wednesday.
With that in mind, do not be surprised if this contest ends in a low-scoring draw, a result which will ensure that they remain on course for the last 16.
Independiente vs. Universitario (Wednesday, 11.00pm)
Los Negriazules have conceded in each of their last seven games in all competitions, while the Peruvian visitors have conceded three times in both of their opening Group A matches.
We say: Independiente del Valle 3-1 Universitario
Both Independiente del Valle and Universitario have struggled defensively in recent weeks so Wednesday's encounter could see plenty of goalmouth action.
The two teams will be keen to get their Copa Libertadores campaigns back on track with a victory, but we feel that the hosts will respond from last week's thrashing by Palmeiras to secure all three points at the Estadio de Liga Deportiva Universitaria.
Santa Fe vs. River Plate (Thursday, 1.00am)
This meeting between the two sides is the first since 2018 when Argentinian outfit River Plate came out on top with a 1-0 win, and they eventually went on to win their fourth Copa Libertadores title that year.
We say: Santa Fe 1-2 River Plate
River Plate have not kept a clean sheet in their last four games in all competitions which potentially gives Santa Fe the opportunity of getting on the scoreboard.
However, River Plate are four-time champions of the Copa Libertadores and we expect them to pull away from the bottom two teams in Group D with victory over winless Santa Fe.
Rentistas vs. Cristal (Thursday, 1.00am)
The hosts currently occupy third position in Group E after two rounds of matches, while their visitors are rooted to the bottom of the standings.
We say: Rentistas 1-1 Sporting Cristal
The two sides will fancy their chances of picking up all three points in this one which should make for an entertaining watch. However, we are predicting a share of the spoils in this one with goals at both ends.
Internacional vs. Olimpia (Thursday, 1.00am)
The two teams, along with fellow Group B sides Always Ready and Deportivo Tachira, have three points each after winning and losing in their opening two games.
We say: Internacional 2-0 Olimpia
Internacional have won three of their last five games in all competitions, scoring 15 goals in the process, while Olimpia have conceded in each of their last six matches.
The hosts will be heading into Wednesday's fixture as the favourites and we feel that their firepower in attack can help secure all three points at the Estadio Jose Pinheiro Borda.
Catolica vs. Nacional (Thursday, 3.00am)
The Chilean outfit have failed to score in four of their last five matches in all competitions, while their Uruguayan visitors have conceded six goals from their opening two Group F games this season.
We say: Universidad Catolica 0-1 Nacional
Universidad Catolica have kept just four clean sheets from 18 games in all competitions since the turn of the year, while Club Nacional have scored 11 goals in their last six matches.
Both sides need to win to keep their hopes of progressing to the knockout stages alive, but we feel that the visitors have the slight edge and may secure a slender victory in the Chilean capital.