Schalke coach Huub Stevens has opted to give a start to impressive young winger Julian Draxler, with Tranquillo Barnetta on the bench this afternoon.
Draxler lines up on the left of midfield with Jefferson Farfan, as expected, taking his place on the right wing in support of Klaas-Jan Huntelaar.
The visitors, Eintracht Frankfurt, have lone striker Karim Matmour leading the line, with Japanese midfielder Takashi Inui in support.
Schalke: Unnerstall; Howedes, Matip, Fuchs, Uchida; Jones, Neustadter; Draxler, Farfan, Holtby; Huntelaar
Frankfurt: Trapp; Jung, Zambrano, Oczipka, Anderson; Aigner, Schwegler, Meier, Rode, Inui; Matmour