Schalke 04 summer signing Adam Szalai has been selected to lead the line for his side in the absence of the injured Klaas-Jan Huntelaar.
Szalai will be supported from out wide by Julian Draxler and Christian Clemens, who start on the left and right respectively.
Hannover have opted for a two-man attack, with former Manchester United striker Mame Biram Diouf partnering Artur Sobiech.
Hannover: Zieler; Sakai, Marcelo, Sane, Pocognoli; Stindl, Prib, Andreasen, Huszti; Diouf, Sobiech
Schalke: Hildebrand; Hoogland, Matip, Howedes, Fuchs; Neustadter, Jones; Goretzka Clemens, Draxler; Szalai