Southampton duo Dejan Lovren and Gaston Ramirez have both been ruled out for up to eight weeks with ankle ligament injuries.
Both players had to be stretchered off during the Saints' 2-2 draw with Sunderland at the Stadium of Light in the Premier League on Saturday.
"The medical staff is preparing a strategy to get them back as soon as possible," Southampton assistant manager Jesus Perez told BBC Radio Solent.
"They have similar ankle injuries, both ligament, one right and the other left ankle. It will be the same period between six and eight weeks."
Southampton are currently ninth in the league table with 31 points from 22 matches.
